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BRAIN R ESEARCH E LSEVIER Brain Research 711 (1996) 163-174 R esearch report E ndotoxin produces a depressive-like episode in rats R az Yirmiya * incision of Psychology, The Hebrew UniL,ersity of Jerusalem, Mount Scopus, Jerusalem 91905, Israel true 31 October 1995 A bstract Activation of the repellent governing body produces mental and physiological effects, which jibe the characteristics of depression. The present study was designed to check further, in rats, the semblance between the portal effects of tolerant activation and a baffle of depression in animals. simplification in the preference for and outlay of saccharin solutions and suppression of sexual behavior were used as models of one inwrought feature of depression, the unfitness to experience pleasure (anhedonia). Other measures interrogatory this model were the step-down in food consumption, body weight, locomotive action mechanism, and cordial interaction. It was found that sys temic injection of lipopolysaccharide (endotoxin), which is a manlike activator of the immune system, significantly change magnitude saccharin preference in fluid-deprived rats. Lipopolysaccharide (LPS) besides decreased free consumption of saccharin, but not water, in non-deprived rats.

some(prenominal) indices of male sexual behavior were significantly suppress hobby LPS administration. Chronic, but not acute, treatment with the tricyclic antidepressant medicate imipramine abolished the restrictive effect of LPS on saccharin preference. Moreover, chronic, but not acute, treatment with imipramine also reduced and facilitated the recovery from the restrictive effects of LPS on food consumption, body weight, social inter! action and activity in the open-field test. The results suggest that activation of the immune system in rats produces anhedonia and early(a) depressive-like symptoms, which can be attenuated or alone block by chronic treatment with an antidepressant drug. Keywords: Lipopolysaccharide; falloff;...If you motivation to get a full essay, order it on our website: OrderEssay.net

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